Overview …
Plinest® and Newest® Polynucleotides are regenerative injectable treatments that focus on improving the quality and function of the skin rather than altering structure or volume.
Derived from highly purified polynucleotides, these treatments work at a cellular level to support tissue repair, stimulate fibroblast activity and encourage collagen and elastin production. They also help improve hydration within the skin, contributing to a healthier, more resilient skin environment.
At Mirabel Clinic, polynucleotides are used where the focus is on skin quality, recovery and regeneration. They are particularly suited to areas where the skin is delicate or showing early signs of change, such as around the eyes, as well as for more generalised concerns relating to texture, laxity and skin fatigue.
In simple terms, Plinest® is typically selected for broader skin rejuvenation, while Newest® is often used in more delicate or targeted areas where a lighter, more refined approach is required.
Treatment is delivered as a course, with results building gradually as the skin responds. Rather than creating immediate visible change, the aim is to support the skin’s own regenerative processes for a more natural and sustained improvement.
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Prices
Newest® course of 3: Dr Brooks £950/Other Practitioner £855
Plinest® course of 3: Dr Brooks £950/Other Practitioner £855
Plinest® eye course of 3: Dr Brooks £750/Other Practitioner £675
Polynucleotides at Mirabel
At Mirabel Clinic, polynucleotides are used as part of a considered, regenerative approach to skin health. Treatment is tailored to the individual, with product selection and placement guided by the condition of the skin and the area being treated. The treatment is performed using a series of small, targeted injections placed within the skin to optimise distribution and response.
A course of treatment is usually recommended, with sessions spaced to allow the skin to respond and remodel progressively.
Do you need to repeat the course?
3 treatments are administered at 3-4 week intervals, to maintain these benefits and support ongoing skin health, the course is usually repeated at intervals of 6 to 12 months, depending on the individual’s skin condition and goals.
What concerns can polynucleotides treat?
Polynucleotides are used to improve skin quality and support regeneration rather than to add volume or reshape features.
They are commonly used for:
• Fine lines and early signs of ageing
• Skin laxity and reduced elasticity
• Dehydrated or fragile skin
• Periocular concerns, including crepey skin around the eyes
• Skin that appears tired, dull or lacking resilience
• Support for skin recovery following other treatments
Suitability depends on the condition of the skin and the treatment goals identified during consultation.
What does the treatment feel like?
The treatment involves a series of small injections into the skin. A topical anaesthetic may be used to improve comfort, particularly in more sensitive areas.
Most patients experience a mild stinging or pressure sensation during injection. Following treatment, there may be temporary swelling, small raised areas at injection points and mild bruising, all of which typically settle within a few days.
The treatment is generally well tolerated, with downtime considered minimal to moderate depending on the area treated.
What results can be expected?
Results develop gradually as the skin responds to the regenerative stimulus provided by the polynucleotides.
Early changes often relate to improved hydration and skin quality, with longer-term improvements seen in texture, elasticity and overall skin resilience as collagen and elastin production increases.
A course of treatments is typically required to achieve optimal results, with maintenance treatments recommended depending on how the skin continues to respond.
Treatment planning and safety
Polynucleotide treatments are selected based on individual skin assessment and suitability. At Mirabel Clinic, they are used where a regenerative approach is appropriate, either as a standalone treatment or alongside other modalities.
As with all injectable treatments, there are considerations around skin health, medical history and treatment timing. Careful planning ensures that treatment is delivered safely and in a way that supports the skin’s natural repair processes.
Aftercare guidance is provided to minimise irritation and support recovery, with particular attention to protecting the skin and allowing the injected product to integrate effectively.
Contraindications and suitability
Polynucleotide treatment may not be suitable in certain circumstances. A full consultation is required to assess individual suitability before proceeding.
Treatment is typically deferred if:
• There is active infection, inflammation or cold sores in the treatment area
• There is a history of severe allergic reactions to dermal fillers or their components
Additional caution may be required if:
• You have certain autoimmune or systemic conditions
• You are taking medications that affect healing or bleeding
• You have had previous filler treatments that require assessment
At Mirabel, all treatments are carried out within a medical framework, with patient safety and appropriate treatment selection as a priority. Where treatment is not suitable, alternative options or timing may be discussed.
